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adenosine thiamine triphosphate : ウィキペディア英語版
adenosine thiamine triphosphate

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Adenosine thiamine triphosphate (AThTP), or thiaminylated adenosine triphosphate, is a natural thiamine adenine nucleotide. It was discovered in ''Escherichia coli'' where it may account for up to 15 - 20% of total thiamine under carbon starvation. AThTP exists also, though at much lower levels, in eukaryotic organisms such as yeast, roots of higher plants and animal tissues. It was found to exist in small amounts in the muscle, heart, brain, kidneys and liver of mice.〔
In ''E. coli'' AThTP is synthesized from thiamine diphosphate (ThDP) according to the following reaction catalyzed by thiamine diphosphate adenylyl transferase:
:ThDP + ATP (ADP) ↔ AThTP + PPi (Pi)
==Structure and function==

The molecule is made up of thiamine an adenine base joinsed together with phosphate groups. It is similar in structure to NAD+. The function of AThTP is not currently know but it has been shown to inhibit the activity of PARP-1.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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